近年来3D成像技术的进步已经允许大型标本的越来越高的分辨率体积图像。由数百个千兆字节的结果数据集大小调用了图像处理领域的新可扩展和内存有效方法，其中已经进行了一些进度。同时，在特定数据大小的可用性和生成相关地面真理数据方面，这些新方法对这些新方法的定量评估难以。在本文中，我们介绍了一种算法框架，可用于有效地生成测试（和地面真理）卷数据，即使以流式方式也是如此。由于提出的嵌套扫描算法快速，它可用于根据需求生成测试数据。我们分析了所提出的算法的渐近运行时间，并将其实验与替代方法以及假设的最佳案例基线方法进行比较。在一个案例研究中，该框架应用于流行的Vascusynth软件，用于血管图像的产生，使得能够有效地产生较大的内存体积，通过产生千氧克素（1TB）图像来证明。所呈现的框架的实现以修改版的Vascusynth和用于实验评估的代码的形式在线提供。此外，测试数据生成过程已集成到流行的卷渲染和处理框架Voreen中。

图像分割的随机沃克方法是半自动图像分割的流行工具，尤其是在生物医学领域。但是，它的线性渐近运行时间和内存要求使应用于增加大小不切实际的3D数据集。我们提出了一个分层框架，据我们所知，这是克服这些随机沃克算法的限制并实现sublinear的运行时间和持续的内存复杂性的尝试。该框架的目的是 - 与基线​​方法相比，而不是改善细分质量，以使交互式分割在核心外数据集中成为可能。确认该方法的合成数据和CT-ORG数据集进行了定量评估，其中确认了算法运行时间的预期改进，同时确认了高分段质量。即使对于数百千兆字节的大小，增量（即互动更新）运行时间也已在标准PC上以秒为单位。在一个小案例研究中，证明了当前生物医学研究对大型现实世界的适用性。在广泛使用的卷渲染和处理软件Voreen（https://www.uni-muenster.de/voreen/）的5.2版5.2版中，介绍方法的实现公开可用。

The analysis of network structure is essential to many scientific areas, ranging from biology to sociology. As the computational task of clustering these networks into partitions, i.e., solving the community detection problem, is generally NP-hard, heuristic solutions are indispensable. The exploration of expedient heuristics has led to the development of particularly promising approaches in the emerging technology of quantum computing. Motivated by the substantial hardware demands for all established quantum community detection approaches, we introduce a novel QUBO based approach that only needs number-of-nodes many qubits and is represented by a QUBO-matrix as sparse as the input graph's adjacency matrix. The substantial improvement on the sparsity of the QUBO-matrix, which is typically very dense in related work, is achieved through the novel concept of separation-nodes. Instead of assigning every node to a community directly, this approach relies on the identification of a separation-node set, which -- upon its removal from the graph -- yields a set of connected components, representing the core components of the communities. Employing a greedy heuristic to assign the nodes from the separation-node sets to the identified community cores, subsequent experimental results yield a proof of concept. This work hence displays a promising approach to NISQ ready quantum community detection, catalyzing the application of quantum computers for the network structure analysis of large scale, real world problem instances.

In this work, a method for obtaining pixel-wise error bounds in Bayesian regularization of inverse imaging problems is introduced. The proposed method employs estimates of the posterior variance together with techniques from conformal prediction in order to obtain coverage guarantees for the error bounds, without making any assumption on the underlying data distribution. It is generally applicable to Bayesian regularization approaches, independent, e.g., of the concrete choice of the prior. Furthermore, the coverage guarantees can also be obtained in case only approximate sampling from the posterior is possible. With this in particular, the proposed framework is able to incorporate any learned prior in a black-box manner. Guaranteed coverage without assumptions on the underlying distributions is only achievable since the magnitude of the error bounds is, in general, unknown in advance. Nevertheless, experiments with multiple regularization approaches presented in the paper confirm that in practice, the obtained error bounds are rather tight. For realizing the numerical experiments, also a novel primal-dual Langevin algorithm for sampling from non-smooth distributions is introduced in this work.

Machine learning (ML) on graph-structured data has recently received deepened interest in the context of intrusion detection in the cybersecurity domain. Due to the increasing amounts of data generated by monitoring tools as well as more and more sophisticated attacks, these ML methods are gaining traction. Knowledge graphs and their corresponding learning techniques such as Graph Neural Networks (GNNs) with their ability to seamlessly integrate data from multiple domains using human-understandable vocabularies, are finding application in the cybersecurity domain. However, similar to other connectionist models, GNNs are lacking transparency in their decision making. This is especially important as there tend to be a high number of false positive alerts in the cybersecurity domain, such that triage needs to be done by domain experts, requiring a lot of man power. Therefore, we are addressing Explainable AI (XAI) for GNNs to enhance trust management by exploring combining symbolic and sub-symbolic methods in the area of cybersecurity that incorporate domain knowledge. We experimented with this approach by generating explanations in an industrial demonstrator system. The proposed method is shown to produce intuitive explanations for alerts for a diverse range of scenarios. Not only do the explanations provide deeper insights into the alerts, but they also lead to a reduction of false positive alerts by 66% and by 93% when including the fidelity metric.

Earthquakes, fire, and floods often cause structural collapses of buildings. The inspection of damaged buildings poses a high risk for emergency forces or is even impossible, though. We present three recent selected missions of the Robotics Task Force of the German Rescue Robotics Center, where both ground and aerial robots were used to explore destroyed buildings. We describe and reflect the missions as well as the lessons learned that have resulted from them. In order to make robots from research laboratories fit for real operations, realistic test environments were set up for outdoor and indoor use and tested in regular exercises by researchers and emergency forces. Based on this experience, the robots and their control software were significantly improved. Furthermore, top teams of researchers and first responders were formed, each with realistic assessments of the operational and practical suitability of robotic systems.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Modeling perception sensors is key for simulation based testing of automated driving functions. Beyond weather conditions themselves, sensors are also subjected to object dependent environmental influences like tire spray caused by vehicles moving on wet pavement. In this work, a novel modeling approach for spray in lidar data is introduced. The model conforms to the Open Simulation Interface (OSI) standard and is based on the formation of detection clusters within a spray plume. The detections are rendered with a simple custom ray casting algorithm without the need of a fluid dynamics simulation or physics engine. The model is subsequently used to generate training data for object detection algorithms. It is shown that the model helps to improve detection in real-world spray scenarios significantly. Furthermore, a systematic real-world data set is recorded and published for analysis, model calibration and validation of spray effects in active perception sensors. Experiments are conducted on a test track by driving over artificially watered pavement with varying vehicle speeds, vehicle types and levels of pavement wetness. All models and data of this work are available open source.

Large, text-conditioned generative diffusion models have recently gained a lot of attention for their impressive performance in generating high-fidelity images from text alone. However, achieving high-quality results is almost unfeasible in a one-shot fashion. On the contrary, text-guided image generation involves the user making many slight changes to inputs in order to iteratively carve out the envisioned image. However, slight changes to the input prompt often lead to entirely different images being generated, and thus the control of the artist is limited in its granularity. To provide flexibility, we present the Stable Artist, an image editing approach enabling fine-grained control of the image generation process. The main component is semantic guidance (SEGA) which steers the diffusion process along variable numbers of semantic directions. This allows for subtle edits to images, changes in composition and style, as well as optimization of the overall artistic conception. Furthermore, SEGA enables probing of latent spaces to gain insights into the representation of concepts learned by the model, even complex ones such as 'carbon emission'. We demonstrate the Stable Artist on several tasks, showcasing high-quality image editing and composition.

Object detection requires substantial labeling effort for learning robust models. Active learning can reduce this effort by intelligently selecting relevant examples to be annotated. However, selecting these examples properly without introducing a sampling bias with a negative impact on the generalization performance is not straightforward and most active learning techniques can not hold their promises on real-world benchmarks. In our evaluation paper, we focus on active learning techniques without a computational overhead besides inference, something we refer to as zero-cost active learning. In particular, we show that a key ingredient is not only the score on a bounding box level but also the technique used for aggregating the scores for ranking images. We outline our experimental setup and also discuss practical considerations when using active learning for object detection.